Spybot - Search & Destroy has detected a change to a Browser Helper Object.
Spybot-S&D Resident watches for new or deleted Browser Helper Objects (which are plugins for Internet Explorer, sometimes expanding its functionality, but often used for malicious purposes as well).
Did you just try to install some Internet Explorer plugin? If it's not shown as a bad one, you should proceed. If this happens out of the blue sky while surfing the web, you should get catious.